Objective. The objective of this study was to find out the possible antiulcer mechanism of action of Eremomastax speciosa. Method.\nCarbachol- and histamine-induced hypersecretion, associated with the pylorus ligation technique, were used in rats. Gastric\nmucosal ulceration, mucus production, pH, gastric volume, and acidity were measured. Results. Histamine and carbachol raised\ngastric acidity to 86.50 and 84.80 mEq/L, respectively, in the control rats, and the extracts (200mg/kg) reduced gastric acidity to\n34.60 and 39.00mEq/L, respectively. Intraduodenal aqueous extract (400mg/kg) in histamine- and carbachol-treated rats produced\nsignificant (?? < 0.001) decreases in acid secretion to 28.50 and 28.80mEq/L, respectively, and 100 percent inhibition of gastric\nulceration. Augmented histamine-induced gastric acid secretion (90.20mEq/L) was significantly reduced to 52.60 and 27.50mEq/L\nby the 200 and 400mg/kg doses of the aqueous extract, respectively.The extract significantly reduced (?? < 0.001) the volume of\ngastric secretion and significantly increasedmucus production.Theulcer inhibition potential of the extract significantly dropped to\n25ââ?¬â??44% (oral extract) and to 29ââ?¬â??37% (duodenal extract) in carbachol/indomethacin-treated rats. Conclusion. The aqueous extract\nof E. speciosa has both cytoprotective and antisecretory effects.The antisecretory effect may involve a mechanism common to both\ncholinergic and histaminergic pathways.
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